In Precise Tumor, which tier indicates FDA-approved therapy in the same cancer?

In Precise Tumor, which tier indicates FDA-approved therapy in the same cancer?

• A. Tier IA
• B. Tier I
• C. Tier II
• D. Tier III

Answer: (A)

In Precise Tumor, tiers reflect how strong the evidence and regulatory approval are for a biomarker-directed therapy in a given cancer. Tier IA specifically means there is an FDA-approved therapy for this exact cancer, with the indication and labeling supporting use in the patient’s tumor type. This makes it the best choice because it represents a therapy that is approved for the same cancer and is typically considered standard of care when the biomarker is present, backed by robust clinical evidence. Other tiers cover therapies that may be FDA-approved but for a different cancer or context, or therapies supported by less direct or lower-quality evidence (such as non–FDA-approved uses, trials, or extrapolated data). So while those tiers can still be informative, they do not indicate an FDA-approved, same-cancer therapy in the way Tier IA does.

In Precise Tumor, tiers reflect how strong the evidence and regulatory approval are for a biomarker-directed therapy in a given cancer. Tier IA specifically means there is an FDA-approved therapy for this exact cancer, with the indication and labeling supporting use in the patient’s tumor type. This makes it the best choice because it represents a therapy that is approved for the same cancer and is typically considered standard of care when the biomarker is present, backed by robust clinical evidence.

Other tiers cover therapies that may be FDA-approved but for a different cancer or context, or therapies supported by less direct or lower-quality evidence (such as non–FDA-approved uses, trials, or extrapolated data). So while those tiers can still be informative, they do not indicate an FDA-approved, same-cancer therapy in the way Tier IA does.